# Locus coeruleus

A brainstem nucleus that supplies noradrenaline to the forebrain and responds to novelty in mice.

**Source:** “LC neurons fire in bursts in novel environments or when encountering unexpected novelty in a familiar environment” [Article PMC8991985 (PubMed Central)](https://pmc.ncbi.nlm.nih.gov/articles/PMC8991985/)

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Published 2026-10-29. Web page: https://www.mackenziebowes.com/reference/glossary/locus-coeruleus